Next-Gen Nanobubble Technology

Advanced Oxygenation for
Cell Culture Excellence

Delivering precise oxygen control for improved cell growth and performance in advanced culture applications.

Integrating nanobubble technology into cell culture and bioprocess systems enhances oxygen transfer, process control, and overall system stability. These ultra-fine bubbles improve gas–liquid interaction, support uniform distribution of nutrients and gases, and create more controlled biological environments.

The result is improved cell growth, higher productivity, reduced variability, and more consistent, efficient bioprocess performance.

The NICO BIOGEN Advantage

The NICO BIOGEN Nanobubble System improves oxygen delivery and process stability across cell culture and bioprocess applications. By enhancing gas–liquid interaction through ultra-fine nanobubbles, it supports stronger cell growth and consistent biological performance.

Designed for seamless integration with bioreactors and lab systems, it enables efficient and reliable bioprocessing.

> 85% Gas Transfer Efficiency
< 200nm Bubble Diameter
The NICO VANTA

Key Application Areas

Powered by advanced nanobubble technology for improved efficiency and stability.

Beverage oxygen

Cell culture
oxygenation

Enhances oxygen availability to support healthier, faster, and more efficient cell growth.

Commercial

Stem cell growth
optimization

Maintains stable culture conditions to improve stem cell viability, expansion, and performance.

CIP & sanitation

Bioreactor oxygen
transfer

Improves gas transfer efficiency for consistent and reliable bioreactor operation.

Fruit & vegetable

Protein & vaccine
production

Enhances productivity and process consistency in biopharmaceutical manufacturing.

Fermentation

High-density
bioprocessing

Enables efficient oxygen delivery to support high cell density cultures and improved output.

Dairy & processing

Bioprocess
development

Supports accurate testing, optimization, and scaling of biological processes.

Key Benefits

Driving measurable gains in cell growth, process efficiency, and system
performance across bioprocess applications.

View Case Studies View case Studies
Optimized Beverage
Enhanced Oxygen Transfer &
Stability

Improves oxygen transfer efficiency and maintains stable dissolved oxygen levels in culture media.

Enhanced Hygiene &
Optimized Cell Growth &
Viability

Supports healthy growth and performance of sensitive mammalian and stem cell cultures.

Improved Processing
Improved Bioprocess
Performance

Enhances bioreactor efficiency and ensures greater process consistency and control.

Quality Consistency
Scalable & Easy
Integration

Designed for seamless integration across research, development, and scale-up in lab and pilot systems.

Technical Specifications

Choose the right NICO BIOGEN model to enhance cell culture performance, oxygenation efficiency, and bioprocess stability.

Models Units NICO BIOGEN 0.05 NICO BIOGEN 0.4
Flow Rate m³/hr 0.054 0.36
LPH 54 360
System Pressure bar 2 1.4
Nanobubble Size nm 50-200 50-200
Zeta potential mV up to -43 mV up to -43 mV
Gas usage Air, Oxygen Oxygen
Oxygen Flow Rate LPM 0.7 1.2
Oxygen Pressure PSI >7 >7
Ozone Flow Rate GPH -NA- -NA-
Ozone Pressure PSI -NA- -NA-
Suction Line Size inch -NA- 12mm tube
Discharge Line Size inch -NA- 12mm tube

Frequently Asked Questions

What applications is the NICO BIOGEN Nanobubble System suitable for?

The system is ideal for mammalian and stem cell culture, bioreactor oxygenation, protein and vaccine production, and high-density bioprocess development across biotech and biopharmaceutical applications.

How does NICO BIOGEN improve cell culture and bioprocess performance?

By generating ultra-fine nanobubbles, it enhances oxygen transfer, stabilizes dissolved oxygen levels, and creates a more controlled environment for improved cell growth, viability, and process consistency.

Can the NICO BIOGEN system be used for both research and production?

Yes. It is designed for laboratory research, process development, and pilot or production-scale bioreactor systems, supporting seamless scale-up and consistent performance.

Advance Your Cell Culture Performance
with Precision Oxygenation