Next-Gen Nanobubble Technology

Precision Oxygenation for
Advanced Cell Culture Applications

Optimize cell culture performance and bioprocess efficiency with the NICO BIOGEN Nanobubble System.

Integrating nanobubble technology into cell culture and bioprocess systems enhances oxygen transfer, process control, and overall system stability. These ultra-fine bubbles improve gas–liquid interaction, support uniform nutrient and gas distribution, and enable more controlled biological environments.

The result is improved cell growth, higher productivity, reduced variability, and more consistent, efficient bioprocess performance.

The NICO BIOGEN Advantage

The NICO BIOGEN Nanobubble System enhances oxygen delivery and stability in cell culture and bioprocess applications. Ultra-fine nanobubbles improve oxygen transfer and gas–liquid interaction, supporting healthier cell growth and consistent performance.

It integrates seamlessly with bioreactors, lab systems, and biotech process platforms for reliable and efficient operations.

> 85% Gas Transfer Efficiency
< 200nm Bubble Diameter
The NICO VANTA

Key Application Areas

Advancing oxygen transfer and bioprocess performance with advanced
nanobubble technology.

Beverage oxygen

Cell culture
oxygenation

Enhances oxygen availability for healthier and more efficient cell growth.

Commercial

Stem cell growth
optimization

Supports stable conditions for improved stem cell viability and expansion.

CIP & sanitation

Bioreactor oxygen
transfer

Improves gas transfer efficiency for consistent bioreactor performance.

Fruit & vegetable

Protein & vaccine
production

Boosts productivity and consistency in biopharmaceutical manufacturing.

Fermentation

High-density
bioprocessing

Enables efficient oxygen delivery for high cell density cultures.

Dairy & processing

Bioprocess
development

Supports reliable testing and optimization of biological processes.

Key Benefits

Measurable improvements in cell growth, bioprocess efficiency, and
overall system performance.

View Case Studies View case Studies
Optimized Beverage
Enhanced Oxygen Transfer &
Stability

Improves oxygen transfer and maintains stable dissolved oxygen levels in culture media.

Enhanced Hygiene &
Optimized Cell Growth &
Viability

Supports healthy growth of sensitive mammalian and stem cell cultures.

Improved Processing
Improved Bioprocess
Performance

Enhances bioreactor efficiency and overall process consistency.

Quality Consistency
Scalable & Easy
Integration

Suitable for research, development, and scale-up with seamless integration into lab and pilot systems.

Technical Specifications

Choose the right NICO BIOGEN model to enhance cell culture performance and bioprocess efficiency.

Models Units NICO BIOGEN 0.05 NICO BIOGEN 0.4
Flow Rate m³/hr 0.054 0.36
LPH 54 360
System Pressure bar 2 1.4
Nanobubble Size nm 50-200 50-200
Zeta potential mV up to -43 mV up to -43 mV
Gas usage Air, Oxygen Oxygen
Oxygen Flow Rate LPM 0.7 1.2
Oxygen Pressure PSI >7 >7
Ozone Flow Rate GPH -NA- -NA-
Ozone Pressure PSI -NA- -NA-
Suction Line Size Millimeter -NA- 12mm tube
Discharge Line Size Millimeter -NA- 12mm tube

Frequently Asked Questions

What applications is the NICO BIOGEN Nanobubble System suitable for?

The system is ideal for mammalian and stem cell culture, bioreactor oxygenation, protein and vaccine production, and high-density bioprocess development in biotech and biopharmaceutical applications.

How does NICO BIOGEN improve cell culture and bioprocess performance?

By generating ultra-fine nanobubbles, it enhances oxygen transfer, stabilizes dissolved oxygen levels, and creates a more controlled environment for improved cell growth, viability, and process consistency.

Can the NICO BIOGEN system be used for both research and production?

Yes, it is designed for use in laboratory studies, process development, and pilot-scale or production bioreactor systems, supporting scale-up and consistent performance.

Advance Your Cell Culture Performance
with Precision Oxygenation